DHEA and ubiquinol to help low AMH

So, as soon as I got the result of my AMH test, I started researching supplements that can help with the health of my eggs.

Medical opinions are very mixed in that matter. Some say there is nothing you can do to improve the health of your eggs and others believe that DHEA and ubiquinol can help.

There are no studies on humans for the ubiquinol but a study of mice by Dr. Robert Casper and colleagues at Samuel Lunenfeld Research Institute, showed that CoQ10 supplementation on mid-aged female mice resulted in more pregnancies and more babies per litter. “They found that when CoQ10 was given to 52-week-old mice – about mid-age for a mouse – their eggs appeared to rejuvenate. There were significantly more egg follicles in the old mice treated with the CoQ10…”

Ubiquinol is a better form of CoQ10. I have been taking a daily dose of 300mg of ubiquinol for about 2 months now, that is the equivalent of 600ml CoQ10. I buy it on amazon.

DSCN0076As for DHEA, I asked my consultant and my gyneocologist uncle about it and they both recommend it. Again, the medical profession has mixed opinions about it, some think it is worth taking and other think it does not affect egg health at all. The research I like the most is the one from CHR as they do use it with their patients so they have lots of experience with it. The thing to know is that it may help for those who are over 40, and for those have a low AMH level (even if they are under 40).

I have been taking a daily dose of 75mg of DHEA for about 2 months and a half now. I buy it from a pharmacy in France. I suggest you get it preferably from a pharmacy as they can compound it into a micronised version which is better absorbed by the body, alternatively you can also buy it direct from McPherson Labs or from www.healthmonthly.co.uk (make sure the one you buy is micronised). The only side effect I have is a very slight increase in acne, which I am OK with. One positive thing that I have also noticed is that DHEA does help with my feelings low, since last year this infertility issue has taken a toll on me and since taking the DHEA the number of times that I have felt low have greatly decreased. Here is a list of conditions that may be helped by DHEA supplementation, and depression is among them.

Other than that, I am still endometriosis pain free, thanks to taking letrozole 5 days a month. I will write about my 2nd cycle on letrozole next time.

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Clomid, progesterone and endometriosis

As you know, I am trying to get pregnant. So back in february and march, my gp ordered some blood tests and these are the results:

  • UE – U&E (electrolytes): fine
  • TFT1 – Thyroid function – thyroid disease?: fine
  • FBC – Full blood count: fine
  • LH: fine
  • FSH: fine
  • Progesterone: to low
    • My progesterone level in february was 17 (during that month, my monthly cycle was only 25 days)
    • My progesterone level in march was 21 (I have taken some tribulus terrestris tablets for the 1st time that month, so this may have helped to increase the progesterone a bit), (during that month, my monthly cycle was only 24 days)

This means that I may have not ovulated as progesterone level should be at least 30, and below that is a sign of anovulation. I use a Clearblue advanced fertility monitor, and I always get some highs and peaks (when there is a surge of LH – luteinizing hormone – and a rise in the estrogen homone)  every month so I assumed that I was ovulating every month.

I recently learned that women with endometriosis have low progesterone and would benefit from supplementing with natural progesterone whether they want to get pregnant or not.

I then asked my gp to prescribe me some natural progesterone but she said that as a primary care doctor she cannot prescribe that, I will have to wait to see the consultant gyneacologist at the hospital. I was so frustrated as it may take months to get the consultant appointment and I wanted help asap to ovulate. I then decided to try clomid and progesterone and asked one of my uncles (a gyneacologist  who lives in France) to prescribe me some.

clomid progesteroneMy dad bought them in a pharmacy in France and posted them to me (I am in UK).

My prescription was:

  • 1st month: 50mg clomid cycle day 3 to 7, progesterone 200mg after ovulation for 10 days
  • 2nd month: 100mg clomid cycle day 3 to 7, progesterone 200mg after ovulation for 10 days
  • 3rd month: 150mg clomid cycle day 3 to 7, progesterone 200mg after ovulation for 10 days
  • 4th month: have a one month pause and then re-assess the situation

I only took clomid and progesterone for 1 month.

Clomid is the 1st medicine doctors prescribe for those who need help ovulating. My research says that clomid can aggravate endometriosis (it also says so in the leaflet) so it is not the best for those who have endometriosis, that Femara is better. I really wanted to know if I can ovulate on clomid so I took it for one month (from cycle day 3 to 7), progesterone was taken the same month (for 10 days starting after ovulation – which I estimated at day 4 after the last peak sign on my fertility monitor, I wanted to be careful with the dates as progesterone taken before ovulation will cause you not to ovulate).

Well, I did not get pregnant that month. I was not monitored and it is really best to be monitored so that you can check how clomid affects you.

But I learned a few things:

While on 50mg clomid, I continued taking my enzymes (serrapeptase, nattokinase, wobenzym N) from cycle day 1 till it was time to take the progesterone. I had more endometriosis pain than usual, much stronger pain but not agonising so I took some 2 paracetamols and 1 co-codamol (30mg tablets) whenever necessary. It was clear that in my case, clomid aggravated my endometriosis pain .

While on progesterone, I decided not to take any enzymes (serrapeptase, nattokinase, wobenzym N) as I really wanted to know how good progesterone can be for those having endometriosis, as some specialists say (Dr John Lee, and Dr Sandra Cabot). Well, I had no endometriosis pain at all and I actually felt really good physically and emotionally.

Clomid stays in your body, so it can still have some effects on your body for a while, even after you have finished taking it. The next month/cycle after taking it, I had dark brown blood for several days from cycle day 17, and it was accompanied by agonising pain so I had to take a dose of 100mg diclofenac suppository. I was back on my enzymes since cycle day 1, so I did not anticipate having any pain so I guess the pain was caused by the clomid residue in my body. I wasn’t sure if this was classified as a period so I asked my uncle and he said it is called mid cycle spotting, I have never had that before so was worried.

Have you tried clomid (or femara or another type of ovulation inducing medicine), and if yes how did it affect your endometriosis? Have you tried any progesterone therapy for your endometriosis or for fertility? By the way, the progesterone I took was a natural micronised one, 200mg, one tablet a day, to be taken orally or vaginally (the most recommended way).